Most of us like the idea of superpowers. Though we may never have the strength of Superman, we could be made stronger, faster, and even better-looking, with total control over our genome, or genetic makeup. What about becoming disease-resistant, weight gain resistant, and even slowing down the aging process? This might be possible in decades to come, as geneticists are now getting ever closer to, not just removing and replacing genes, but rewriting entire genomes. It sounds like the realm of science fiction. Yet, consider that geneticists at Harvard recently recoded the genome of a synthetic E. coli bacteria. Prof. George Church and colleagues conducted the study.
Researchers replaced 62,214 base pairs of DNA. What they have done is recreate the DNA from scratch, though they haven’t actually brought the bacteria to life, yet. What was once thought impossible is no longer. This is the first synthetic genome ever assembled, and is being hailed as the most complex feat of genetic engineering, thus far.
With this technique, we could create any kind of life form we wanted, reprogram organisms, and even create synthetic proteins and compounds. MIT bioengineer Peter Carr, told the journal Science, “It’s not easy, but we can engineer life at profound scales.” Note that he was not involved in this project. So how exactly are they rewriting a genome? DNA is made up of four nucleobases which arrange themselves as base pairs, A and T, C and G. These create one strand of the double helix, known as RNA.